Heavy Metals

08 December 2019
Author :  

Environmental carcinogens' (heavy metals, PAHs, and pesticides) concentration assessment in Iranian adult's blood and urine to determine local standards (local coefficients) by examining drinking water, inhaled air and food consumed by the participants in the study to measure the exposure level in 2018

 

Goals:

  • Determination of the difference between the concentrations of heavy metals, PAHS and pesticides in blood and urine of Iranian adult population and international guidelines.
  • Determination of the concentration of heavy metals (Pb, Zn, Ni, Cr,Hg,Cd and Al) in blood; and levels of Metabolits 1 – hydroxy pyren (1-OHP) and 3-phenoxybenzoic acid (3-PBA) in urine of Iranian adult population.
  • Determination of the relationship between heavy metals, PAHS and pesticides intake and concentration of this pollutants in the blood and urine of Iranian adult population.
  • Comparison of the concentration of heavy metals, PAHs and pesticide by diet, air and water in Iranian adult population with International guidelines.
  • Determination of the difference between the concentrations of heavy metals, PAHS and pesticides in blood and urine of Iranian adult population and international guidelines.

A representative sample size of 1,000 adults at the national and regional levels is estimated based on the population of the region under study and the current condition of the carcinogenic contaminants. In the sampled population (based on sample size), blood and urine biomarkers of the subjects will be sampled for analysis of the carcinogens levels (heavy metals, PAHs and pesticides) in serum and urine. Then, in each selected province in order to determine the amount of these pollutants in the food of the participants of the study and their intake air and water, and to estimate the allocation of each intake rout in contaminants exposure samples of water, food and air will also be taken. Sampling and measurement of these contaminants will be carried out according to the standard methods recommended by the international guideline       

due to the presence of different contaminations in different parts of the country (dust pollution in the southwest and water pollution due to natural pollution sources such as high levels of arsenic in some cities in Kurdistan and Golestan Provinces and the discharge of recombinant contaminants in effluents into the water resources). The results of this research consist: distribution of accumulative concentration of heavy metals, PAHs, and Pesticides at the individual level and the effect of geographical, socioeconomic, lifestyle, and demographic factors on these distributions; these results can be used as a solid evidence for setting standards for the studied contaminants. Also, using the contaminants dose in blood and urine biomarkers, and epidemiological methods, carcinogenicity and death from cancer may be estimated

Contact Info

  • Non-Communicable Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences

    No. 10, Al-e-Ahmad and Chamran Highway intersection, Tehran

    Postcode: 1411713136

  • +9821-88631293
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

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